93 research outputs found
Three-dimensional central-moments-based lattice Boltzmann method with external forcing: A consistent, concise and universal formulation
The cascaded or central-moments-based lattice Boltzmann method (CM-LBM) is a
robust alternative to the more conventional BGK-LBM for the simulation of
high-Reynolds number flows. Unfortunately, its original formulation makes its
extension to a broader range of physics quite difficult. To tackle this issue,
a recent work [A. De Rosis, Phys. Rev. E 95, 013310 (2017)] proposed a more
generic way to derive concise and efficient three-dimensional CM-LBMs. Knowing
the original model also relies on central moments that are derived in an adhoc
manner, i.e., by mimicking those of the Maxwell-Boltzmann distribution to
ensure their Galilean invariance a posteriori, a very recent effort [A. De
Rosis and K. H. Luo, Phys. Rev. E 99, 013301 (2019)] was proposed to further
generalize their derivation. The latter has shown that one could derive
Galilean invariant CMs in a systematic and a priori manner by taking into
account high-order Hermite polynomials in the derivation of the discrete
equilibrium state. Combining these two approaches, a compact and mathematically
sound formulation of the CM-LBM with external forcing is proposed. More
specifically, the proposed formalism fully takes advantage of the D3Q27
discretization by relying on the corresponding set of 27 Hermite polynomials
(up to the sixth order) for the derivation of both the discrete equilibrium
state and the forcing term. The present methodology is more consistent than
previous approaches, as it properly explains how to derive Galilean invariant
CMs of the forcing term in an a priori manner. Furthermore, while keeping the
numerical properties of the original CM-LBM, the present work leads to a
compact and simple algorithm, representing a universal methodology based on CMs
and external forcing within the lattice Boltzmann framework.Comment: Published in Phys. Fluids as Editor's Pic
High speed video capture for mobile phone cameras
We consider an electromechanical model for the operation of a voice coil motor in a mobile phone camera, with the aim of optimizing how a lens can be moved to a desired focusing motion. Although a methodology is developed for optimizing lens shift, there is some concern about the experimentally-determined model parameters that are at our disposal. Central to the model is the value of the estimated magnetic force constant, Kf: its value determines how far it is actually possible to move lens, but it appears that, from the value given, it would not be possible to shift the lens through the displacements desired. Furthermore, earlier experiments have also estimated the value of the back EMF constant, Kg , to be roughly five times greater than Kf, even though we present two theoretical arguments that show that Kf = Kg: a conclusion supported by readily-available manufacturers’ data
Ground State Energy of the One-Component Charged Bose Gas
The model considered here is the `jellium' model in which there is a uniform,
fixed background with charge density in a large volume and in
which particles of electric charge and mass move --- the
whole system being neutral. In 1961 Foldy used Bogolubov's 1947 method to
investigate the ground state energy of this system for bosonic particles in the
large limit. He found that the energy per particle is in this limit, where .
Here we prove that this formula is correct, thereby validating, for the first
time, at least one aspect of Bogolubov's pairing theory of the Bose gasComment: 38 pages latex. Typos corrected.Lemma 6.2 change
Lattice Boltzmann for Binary Fluids with Suspended Colloids
A new description of the binary fluid problem via the lattice Boltzmann
method is presented which highlights the use of the moments in constructing two
equilibrium distribution functions. This offers a number of benefits, including
better isotropy, and a more natural route to the inclusion of multiple
relaxation times for the binary fluid problem. In addition, the implementation
of solid colloidal particles suspended in the binary mixture is addressed,
which extends the solid-fluid boundary conditions for mass and momentum to
include a single conserved compositional order parameter. A number of simple
benchmark problems involving a single particle at or near a fluid-fluid
interface are undertaken and show good agreement with available theoretical or
numerical results.Comment: 10 pages, 4 figures, ICMMES 200
Brewing of filter coffee
We report progress on mathematical modelling of coffee grounds in a drip filter coffee machine. The report focuses on the evolution of the shape of the bed of coffee grounds during extraction with some work also carried out on the chemistry of extraction. This work was sponsored by Philips who are interested in understanding an observed correlation between the final shape of the coffee grounds and the quality of the coffee. We used experimental data gathered by Philips and ourselves to identify regimes in the coffee brewing process and relevant regions of parameter space. Our work makes it clear that a number of separate processes define the shape of the coffee bed depending on the values of the parameters involved e.g. the size of the grains and the speed of fluid flow during extraction. We began work on constructing mathematical models of the redistribution of the coffee grounds specialised to each region and on a model of extraction. A variety of analytic and numerical tools were used. Furthermore our research has progressed far enough to allow us to begin to exploit connections between this problem and other areas of science, in particular the areas of sedimentology and geomorphology, where the processes we have observed in coffee brewing have been studied
In sickness and in health : The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Pathology
It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of most, if not all, normal physiological systems. However, the majority of our knowledge about EV signalling has come from studying them in disease. Indeed, EVs have consistently been associated with propagating disease pathophysiology. The analysis of EVs in biofluids, obtained in the clinic, has been an essential of the work to improve our understanding of their role in disease. However, to interfere with EV signalling for therapeutic gain, a more fundamental understanding of the mechanisms by which they contribute to pathogenic processes is required. Only by discovering how the EV populations in different biofluids change-size, number, and physicochemical composition-in clinical samples, may we then begin to unravel their functional roles in translational models in vitro and in vivo, which can then feedback to the clinic. In Part II of this review series, the functional role of EVs in pathology and disease will be discussed, with a focus on in vivo evidence and their potential to be used as both biomarkers and points of therapeutic intervention.Peer reviewe
In sickness and in health : The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Pathology
It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of most, if not all, normal physiological systems. However, the majority of our knowledge about EV signalling has come from studying them in disease. Indeed, EVs have consistently been associated with propagating disease pathophysiology. The analysis of EVs in biofluids, obtained in the clinic, has been an essential of the work to improve our understanding of their role in disease. However, to interfere with EV signalling for therapeutic gain, a more fundamental understanding of the mechanisms by which they contribute to pathogenic processes is required. Only by discovering how the EV populations in different biofluids change-size, number, and physicochemical composition-in clinical samples, may we then begin to unravel their functional roles in translational models in vitro and in vivo, which can then feedback to the clinic. In Part II of this review series, the functional role of EVs in pathology and disease will be discussed, with a focus on in vivo evidence and their potential to be used as both biomarkers and points of therapeutic intervention.Peer reviewe
In sickness and in health : The functional role of extracellular vesicles in physiology and pathology in vivo Part I: Health and Normal Physiology
Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are now known to mediate physiological and pathological functions throughout the body. We now understand more about their capacity to transfer nucleic acids and proteins between distant organs, the interaction of their surface proteins with target cells, and the role of vesicle-bound lipids in health and disease. To date, most observations have been made in reductionist cell culture systems, or as snapshots from patient cohorts. The heterogenous population of vesicles produced in vivo likely act in concert to mediate both beneficial and detrimental effects. EVs play crucial roles in both the pathogenesis of diseases, from cancer to neurodegenerative disease, as well as in the maintenance of system and organ homeostasis. This two-part review draws on the expertise of researchers working in the field of EV biology and aims to cover the functional role of EVs in physiology and pathology. Part I will outline the role of EVs in normal physiology.Peer reviewe
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